Uppsala University UU (Sweden, Per Eriksson)

Website: www.uu.se


Contribution to CEREBRAD

Within CEREBRAD, studies from Uppsala university will identify the lowest doses of radiation which can contribute to and/or induce reduced cognitive function, and how co-exposure to ionizing radiation and environmental toxicants can interact to shift the shape of the dose response curve and threshold value for ionizing radiation. To date, preliminary studies showed dose response effects from one single dose ( 0 – 1 Gy) of gamma radiation, when given during a defined critical period of neonatal brain development. Also, studies on co-exposure of gamma radiation together with environmental toxicants such as methyl mercury, brominated flame retardants (PBDE 99) and nicotine were conducted, which revealed that this neonatal co-exposure can exacerbate developmental neurotoxic effects and alter the dose-response curve, resulting in a lowering of the threshold dose. Furthermore, the developmental neurotoxic effects could be observed at doses where neither gamma radiation nor the environmental agents caused any behavioural effects. Data have been presented at international meetings such as MELODI, SOT (Society of Toxicology), EUROTOX (European Society of Toxicology), and at Neuroscience.

Working hypothesis of change in the dose response curve after exposure to ionizing radiation, alone and in combination with environmental toxicants.