National Research Center for Radiation Medicine of the Academy of Medical Sciences RCRM (Ukraine, Dimitry Bazika)


Contribution to CEREBRAD

In the CEREBRAD project, RCRM performs quantitative cognitive function analysis using MMSE, GHQ-28, Wechsler and other scales, qEEG, relative telomere length, TERT, TRF1 and TRF2 genes expression in groups of cleanup workers  exposed to external whole body irradiation at doses less than 500 mSv and subjects exposed to ionizing radiation in utero. The subjects have been interviewed to diagnose cognitive dysfunction, revealing 38.8% of mild cognitive impairments and 15.3% of vascular dementia. In individuals exposed to irradiation in utero, as compared to control individuals, preliminary data testify to mild cognitive impairment and intellectual disharmony as well as a decreased relative telomere length.

Postradiation mild cognitive impairment. Red — severe disorders; orange —moderate disorders; yellow —mild disorders; green  — no disorders. (Figure adapted from K. Loganovsky, et al. (2011): Nervous System and Psychosocial Aspects).

Correlations in changes of relative telomere length (red) and cognitive function by MMSE (blue) in groups of cleanup workers (1) and age-standardized control (2) (From RCRM report 2012).