Institut Gustave Roussy IGR, INSERM Unit 1018 (France, Florent de Vathaire)

Website: www.igr.fr


Contribution to CEREBRAD

In CerebRad, IGR/ INSERM is involved and is the Leader of WP2, of which the goal is to evaluate, in the setting of a case control-study, the risk of stroke from low to moderate doses of radiation received during childhood for treatment of cancer. The research details are the following:

To investigate the dose-response relationship between the radiation doses received by the brain, the heart, the lung and the main vessels, and the risk of long term risks of developing cerebrovascular diseases following childhood cancer radiotherapy.
Significant results:

  • Protocol and Manual for data collection written (Cardiac diseases case-control Study Manual for Data Collection).
  • 55 Cases and 55 controls from the FCCSS selected; we expect to include at least 150 cases of cerebrovascular disease and 150 controls in CerebRad, what is more than the 50 cases and 50 controls planed in the initial protocol.
  • Collection of clinical and chemotherapy data complete for the 55 cases and 55 controls of the FCCSS.
  • A “Manual of Brain Structures Delineation” has been established (ref.: CEREBRAD_WP2_MA02): Definition of brain structures- achieved
  • Models of Brain arteries, brain structures and whole body phantoms are being developed for radiation dose reconstruction.
  • Conversion of the models in DICOM format to be compatible with conventional radiotherapy tools (Treatment Planning System), in progress.

To evaluate neurocognitive consequences that on patients treated for hemangioma in childhood.

To evaluate neurocognitive consequences which can be caused by low-dose radiation in persons exposed in utero during and after the Chernobyl accident and the possible role of aging based on telomere length analysis.

To perform the statistical analysis of the risk factors for cerebrovascular disease and cognitive impairment in the cases-control and exposed – non exposed studies.

Illustrations of brain delineation. Transverse cross section, sagittal cross section and 3D reconstruction shows the different brain structures. The yellow spherical region corresponds to the anterior-communicating-artery, the anterior-cerebral-artery, the posterior-cerebral-artery and the posterior-communicating-artery

Illustrations of conversion from phantoms to DICOMs.