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WP4: BIOLOGICAL CONSEQUENCES OF LOW-DOSE IONIZING RADIATION EXPOSURE OF THE CENTRAL NERVOUS SYSTEM

Workpackage-leader: Pier G. Mastroberardino - EMC, Netherlands

Participants: SCK•CEN, ENEA, HMGU, NRIRR, URV, UU, RCRM, AUTH


Objectives:

Understanding of the actions of radiation on the CNS, and their contribution to chronic pathologies, is still
rudimentary. Effects occurring at low doses cannot be assumed to be uniform throughout the CNS, or to follow the changes seen in proliferating tissues at high doses. WP4 will study the radiobiology of low dose effects on the different CNS regions through 4 tasks.

  • To determine the initial direct events specifically induced by low-dose ionising radiation, which contribute to the etiology of diseases of the CNS, and therefore determine which brain areas and cellular types are mostly affected.
  • To characterize the pathology elicited by low vs high doses of radiation to illustrate the indirect events.
  • To identify a transcriptional and translational fingerprint characteristic for low-dose ionising radiation
  • To use advanced bioinformatics for data integration 

    Activities:

    • Task 4.1: To determine the initial direct events specifically induced by low-dose ionising radiation, which contribute to the etiology of diseases of the CNS, and therefore determine which brain areas and cellular types are mostly affected. (ENEA, SCK•CEN)
    • Task 4.2: To characterize the pathology elicited by low vs high doses of radiation to illustrate the indirect events. (EMC)
    • Task 4.3: To identify a transcriptional and translational fingerprint characteristic for low-dose ionizing radiation. (HMGU, SCK•CEN)
    • Task 4.4: To use advanced bioinformatics for data integration. (AUTH)