HMGU

Helmholtz Zentrum München HMGU (Germany, Soile Tapio)

Website: www.helmholtz-muenchen.de

 

Contribution to CEREBRAD

In the CEREBRAD project, HMGU has started performing proteome and microRNA analyses using the isolated brain of sham and total body irradiated NMRI and C57Bl/6 mice. The analyses have been done in a brain-region specific manner, focusing mainly on the hippocampus and cortex, both regions know to be involved in the short- and long-term memory and spatial navigation. Furthermore, the radiation-induced changes in the proteome of the synaptosomes, isolated synaptic terminals from neurons, are being investigated.
The first results indicate that even a moderate gamma dose of 0.5 Gy is able to induce persistent alterations in the brain proteome, detectable more than six months after exposure to irradiation.

 

Kempf SJ et al. Long-term effects of ionising radiation on the brain: cause for concern? Radiat Environ Biophys. 2013 Mar;52(1):5-16