NRIRR

Orszagos Frederic Joliot-Curie Sugarbiologiai es Sugaregeszsegugyi Kutato Intezet

Hungary

Contact person: Géza Sáfrány

Website: http://www.osski.hu/index_en.php

 

NRIRR is engaged in the research of biological effects of radiation, covering the whole range from physical interaction with matter to the application of radiation in medical, as well as in industrial practices. The radiological knowledge is used in radiotherapy of cancer and in radiation hygiene. The Department of Molecular and Tumor Radiobiology (Head: G. Sáfrány, MD., Ph.D.) and the Department of Cell and Immune Radiobiology (Head: K. Lumniczky, MD., Ph.D.) employs eight scientists, including four with Ph.D. degrees and three Ph.D. students. The staff also includes 2 technicians with permanent employment. The group studied cancer incidence in mice after in utero irradiation and investigated the oncogenic events leading to prenatal irradiation-induced tumours. In order to study individual radiation susceptibility in cancer patients, they established more than 100 primary fibroblast cultures from skin biopsies taken from the patients and correlated the in vitro radiation sensitivity of the fibroblast to the early and late radiation-induced sequel of the patients and the individual radiation susceptibility of cancer patients.

To identify potential biomarkers of individual radiation sensitivity, they performed a whole genome microarray study in radiation sensitive and normal fibroblasts after irradiation. Recently, they have investigated low dose radiationinduced bystander effects and genome instability in primary human fibroblast cells and studied individual sensitivity to non-targeted effects. The group also have investigated low dose effects on the immune system and on the anti-tumour immune surveillance (dendritic cells, T-regs, etc.) in adult mice after single dose irradiation. The following infrastructure is available at NRIRR: animal care facility, cell culture and molecular biology laboratories flow cytometry, quantitative real-time PCR, access to microarray facility.